Diversity in enoyl-acyl carrier protein reductases

Cell Mol Life Sci. 2009 May;66(9):1507-17. doi: 10.1007/s00018-009-8704-7.

Abstract

The enoyl-acyl carrier protein reductase (ENR) is the last enzyme in the fatty acid elongation cycle. Unlike most enzymes in this essential pathway, ENR displays an unusual diversity among organisms. The growing interest in ENRs is mainly due to the fact that a variety of both synthetic and natural antibacterial compounds are shown to specifically target their activity. The primary anti-tuberculosis drug, isoniazid, and the broadly used antibacterial compound, triclosan, both target this enzyme. In this review, we discuss the diversity of ENRs, and their inhibitors in the light of current research progress.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Bacterial Proteins / antagonists & inhibitors
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / physiology*
  • Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific) / antagonists & inhibitors
  • Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific) / chemistry
  • Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific) / physiology*
  • Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / antagonists & inhibitors
  • Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / chemistry
  • Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / physiology*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / metabolism
  • Fungal Proteins / antagonists & inhibitors
  • Fungal Proteins / chemistry
  • Fungal Proteins / physiology
  • Gene Expression Regulation
  • Kinetics
  • Plant Proteins / antagonists & inhibitors
  • Plant Proteins / chemistry
  • Plant Proteins / physiology*

Substances

  • Bacterial Proteins
  • Enzyme Inhibitors
  • Fungal Proteins
  • Plant Proteins
  • Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)
  • Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)