Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130

EMBO J. 1991 Oct;10(10):2839-48.

Abstract

Leukemia inhibitory factor (LIF) is a cytokine with a broad range of activities that in many cases parallel those of interleukin-6 (IL-6) although LIF and IL-6 appear to be structurally unrelated. A cDNA clone encoding the human LIF receptor was isolated by expression screening of a human placental cDNA library. The LIF receptor is related to the gp130 'signal-transducing' component of the IL-6 receptor and to the G-CSF receptor, with the transmembrane and cytoplasmic regions of the LIF receptor and gp130 being most closely related. This relationship suggests a common signal transduction pathway for the two receptors and may help to explain similar biological effects of the two ligands. Murine cDNAs encoding soluble LIF receptors were isolated by cross-hybridization and share 70% amino acid sequence identity to the human sequence.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, CD*
  • Base Sequence
  • Blotting, Northern
  • Cytokine Receptor gp130
  • DNA / genetics
  • Electrophoresis, Polyacrylamide Gel
  • Growth Inhibitors*
  • Humans
  • Interleukin-6 / metabolism*
  • Leukemia Inhibitory Factor
  • Leukemia Inhibitory Factor Receptor alpha Subunit
  • Lymphokines / metabolism*
  • Membrane Glycoproteins / chemistry*
  • Membrane Glycoproteins / metabolism
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA, Messenger / genetics
  • Receptors, Cytokine*
  • Receptors, Immunologic / genetics*
  • Receptors, Immunologic / metabolism
  • Receptors, OSM-LIF
  • Restriction Mapping
  • Sequence Homology, Nucleic Acid
  • Signal Transduction*
  • Substrate Specificity
  • Transcription, Genetic

Substances

  • Antigens, CD
  • Growth Inhibitors
  • IL6ST protein, human
  • Il6st protein, mouse
  • Interleukin-6
  • LIF protein, human
  • LIFR protein, human
  • Leukemia Inhibitory Factor
  • Leukemia Inhibitory Factor Receptor alpha Subunit
  • Lif protein, mouse
  • Lifr protein, mouse
  • Lymphokines
  • Membrane Glycoproteins
  • RNA, Messenger
  • Receptors, Cytokine
  • Receptors, Immunologic
  • Receptors, OSM-LIF
  • Cytokine Receptor gp130
  • DNA

Associated data

  • GENBANK/S57798
  • GENBANK/S57800
  • GENBANK/S58249
  • GENBANK/S60920
  • GENBANK/X56822
  • GENBANK/X60658
  • GENBANK/X60659
  • GENBANK/X60660
  • GENBANK/X60661
  • GENBANK/X61615