FrameDP: sensitive peptide detection on noisy matured sequences

Bioinformatics. 2009 Mar 1;25(5):670-1. doi: 10.1093/bioinformatics/btp024. Epub 2009 Jan 19.


Summary: Transcriptome sequencing represents a fundamental source of information for genome-wide studies and transcriptome analysis and will become increasingly important for expression analysis as new sequencing technologies takes over array technology. The identification of the protein-coding region in transcript sequences is a prerequisite for systematic amino acid-level analysis and more specifically for domain identification. In this article, we present FrameDP, a self-training integrative pipeline for predicting CDS in transcripts which can adapt itself to different levels of sequence qualities.

Availability: FrameDP for Linux (web-server and underlying pipeline) is available at {{}} for direct use or a standalone installation.

MeSH terms

  • Gene Expression Profiling
  • Internet
  • Peptides / chemistry*
  • Sequence Analysis, Protein / methods*
  • Software*


  • Peptides