A fatal case of cerebral oedema with hyponatraemia and massive polyuria after renal transplantation

Pediatr Nephrol. 2009 Jun;24(6):1231-4. doi: 10.1007/s00467-008-1100-y. Epub 2009 Jan 20.


We report the case of a child who died from severe cerebral oedema in the context of hyponatraemia and extreme polyuria immediately after renal transplantation. The patient was treated according to a standard post-transplantation protocol, receiving 0.45% saline solution for urine output replacement. The case highlights the dangers of massive fluid therapy in the context of polyuria and, therefore, the need for intensive monitoring.

Publication types

  • Case Reports

MeSH terms

  • Brain Edema / surgery*
  • Child
  • Fatal Outcome
  • Fluid Therapy
  • Humans
  • Hyponatremia / surgery*
  • Kidney Transplantation*
  • Male
  • Polyuria / drug therapy
  • Polyuria / surgery*