Alcohol Consumption and Transition of Mild Cognitive Impairment to Dementia

Psychiatry Clin Neurosci. 2009 Feb;63(1):43-9. doi: 10.1111/j.1440-1819.2008.01904.x.


Aim: Mild cognitive impairment (MCI) is a prodrome for dementia. Alcohol drinking patterns may affect cognitive functions and the effects may accumulate to a significant level at an advanced age. This study investigated the relationship between alcohol consumption and risks for dementia in a cohort of elderly patients with MCI.

Methods: Patients with suspected cognitive impairment were screened. One hundred and seventy-six patients who met the MCI criteria were enrolled. Lifetime and daily alcohol consumptions were assessed at baseline using a self-report questionnaire answered by patients and their caregivers. Patients were classified according to alcohol consumptions as abstainers, light-moderate and heavy drinkers. Global cognitive functions were assessed periodically with Mini-Mental State Examination (MMSE). Enrolled patients were followed for 2 years.

Results: Of the 176 patients diagnosed as having MCI, 15 (8.5%) died, 13 (7.4%) were lost to follow up, and 66 (37.5%) developed dementia during follow up. Light-moderate alcohol drinkers had better MMSE performance than abstainers (P < 0.05) and heavy drinkers (P < 0.01) 2 years after MCI diagnosis. Patients who consumed a total of <or=300 kg alcohol prior to MCI diagnosis had less cognitive decline than patients who consumed no (P < 0.05) or >300 kg alcohol (P < 0.01). Heavy drinkers had a higher risk for dementia than abstainers (P < 0.05) and light-moderate drinkers (P < 0.05) 2 years after MCI diagnosis.

Conclusions: A J-shaped relationship may exist between alcohol consumption and cognitive decline in MCI patients. Light-moderate alcohol drinking may be associated with decreased risks for dementia in elderly patients with MCI.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Alcohol Drinking / epidemiology
  • Alcohol Drinking / psychology*
  • China / epidemiology
  • Cognition Disorders / epidemiology
  • Cognition Disorders / psychology*
  • Cohort Studies
  • Dementia / epidemiology
  • Dementia / psychology*
  • Disease Progression
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Magnetic Resonance Imaging
  • Male
  • Neuropsychological Tests
  • Risk
  • Risk Factors
  • Tomography, X-Ray Computed