cGMP-dependent protein kinase II and aldosterone secretion

FEBS J. 2009 Feb;276(4):1007-13. doi: 10.1111/j.1742-4658.2008.06839.x. Epub 2008 Jan 13.


ACTH-stimulated aldosterone secretion can be inhibited by atrio-natriuretic peptide/cGMP. The mechanism behind this modulation has been reported to involve cGMP-dependent activation of phosphodiesterase 2 (PDE2) and hydrolysis of cAMP. Recently it was reported that activation of cGMP-dependent protein kinase II (cGKII) stimulated aldosterone secretion in rat zona glomerulosa cells. The zona glomerulosa of the murine adrenal cortex expresses cGKII and PDE2. We used mice with a homozygous inactivation of the cGKII gene to investigate in vivo the potential role of this kinase in aldosterone secretion. Basal plasma renin and aldosterone levels were similar in wild-type and cGKII(-/-) mice. In vivo injection of atrio-natriuretic peptide decreased ACTH-stimulated aldosterone secretion in wild-type mice, but had no effect in cGKII-deficient mice. These results support the view that cGKII modulates aldosterone secretion in the murine adrenal cortex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Cortex / cytology
  • Adrenal Cortex / metabolism
  • Adrenocorticotropic Hormone / pharmacology
  • Aldosterone / blood
  • Aldosterone / metabolism*
  • Animals
  • Atrial Natriuretic Factor / pharmacology
  • Blood Pressure
  • Cyclic GMP-Dependent Protein Kinase Type II
  • Cyclic GMP-Dependent Protein Kinases / genetics
  • Cyclic GMP-Dependent Protein Kinases / physiology*
  • Cyclic Nucleotide Phosphodiesterases, Type 2 / metabolism*
  • Heart Rate
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Renin / blood
  • Zona Glomerulosa / cytology
  • Zona Glomerulosa / metabolism


  • Aldosterone
  • Atrial Natriuretic Factor
  • Adrenocorticotropic Hormone
  • Cyclic GMP-Dependent Protein Kinase Type II
  • Cyclic GMP-Dependent Protein Kinases
  • Prkg2 protein, mouse
  • Prkg2 protein, rat
  • Cyclic Nucleotide Phosphodiesterases, Type 2
  • Renin