Protein-functionalized synthetic antiferromagnetic nanoparticles for biomolecule detection and magnetic manipulation

Angew Chem Int Ed Engl. 2009;48(9):1620-4. doi: 10.1002/anie.200803994.


Direct protein functionalization provides synthetic antiferromagnetic nanoparticles with high chemical specificity and multifunctionality. These nanoparticle-protein conjugates function as improved magnetic labels for biological detection experiments, and exhibit tunable responses to a small external magnetic field gradient, thus allowing the observation of distinctive single nanoparticle motion.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aptamers, Nucleotide / chemistry
  • Biosensing Techniques
  • Magnetics
  • Microscopy, Electron, Scanning
  • Nanoparticles / chemistry*
  • Proteins / chemical synthesis
  • Proteins / chemistry*


  • Aptamers, Nucleotide
  • Proteins