Immunobiology of primary intracranial tumors. Part 1: studies of the cellular and humoral general immune competence of brain-tumor patients

J Neurosurg. 1977 Apr;46(4):467-76. doi: 10.3171/jns.1977.46.4.0467.


Cellular and humoral immune parameters were evaluated in a series of brain-tumor patients, 42 with glioblastoma multiforme, 17 with other anaplastic gliomas, and 17 with meningiomas. A degree of anergy was found, which seems in the group as a whole to be proportional to the degree of anaplasia. In addition, serial bimonthyl testing in individual cases revealed further reduction in certain immune responses coincident with clinical decline.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Viral / analysis
  • Brain Neoplasms / immunology*
  • Brain Neoplasms / therapy
  • Glioblastoma / immunology
  • Glioma / immunology*
  • Glioma / therapy
  • Humans
  • Hypersensitivity, Delayed
  • Immunity*
  • Immunity, Cellular*
  • Immunoglobulin A / analysis
  • Immunoglobulin G / analysis
  • Immunoglobulin M / analysis
  • Meningioma / immunology*


  • Antibodies, Viral
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M