A new wave in treatment of vascular occlusive disease: biodegradable stents--clinical experience and scientific principles

J Vasc Interv Radiol. 2009 Mar;20(3):315-24; quiz 325. doi: 10.1016/j.jvir.2008.11.007. Epub 2009 Jan 20.


Stent-based therapies in percutaneous vascular intervention are associated with significant long-term complications related to in-stent restenosis. A growing body of literature demonstrates the feasibility of biodegradable materials for endovascular stents, which may, in theory, circumvent many of the immunologic and inflammatory response issues seen with long-term metallic stent failure in coronary and peripheral applications. This review describes the history of endovascular stents and the challenges encountered with metallic, drug-eluting, and biodegradable stents. A review of the basic engineering principles of biodegradable stents is provided, along with a discussion of the cellular mechanisms of restenosis.

Publication types

  • Review

MeSH terms

  • Absorbable Implants / trends*
  • Arterial Occlusive Diseases / prevention & control*
  • Blood Vessel Prosthesis / trends*
  • Clinical Trials as Topic*
  • Humans
  • Stents / trends*