A new atisane-type diterpene from the bark of the mangrove plant Excoecaria agallocha

Zhan Chang Wang; Yi Ming Lin; Dan Qin Feng; Cai Huan Ke; Peng Lin; Chong Ling Yan; Jun De Chen

doi:10.3390/molecules14010414

A new atisane-type diterpene from the bark of the mangrove plant Excoecaria agallocha

Molecules. 2009 Jan 16;14(1):414-22. doi: 10.3390/molecules14010414.

Authors

Zhan Chang Wang¹, Yi Ming Lin, Dan Qin Feng, Cai Huan Ke, Peng Lin, Chong Ling Yan, Jun De Chen

Affiliation

¹ Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, China.

Abstract

A new atisane-type diterpene, ent-16alpha-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16alpha-hydroxy-atisane-3-one (1), ent-atisane-3beta,16alpha-diol (2), ent-3,4-seco-16alpha-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC(50) value of 0.54+/-0.01 ppm.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biofilms
Diterpenes / chemistry
Diterpenes / isolation & purification*
Euphorbiaceae / chemistry*
Humans
Mass Spectrometry / methods
Models, Molecular
Nuclear Magnetic Resonance, Biomolecular
Plant Bark / chemistry*

Substances

Diterpenes