Does Helicobacter pylori-induced inflammation of gastric mucosa determine the severity of symptoms in functional dyspepsia?

J Gastroenterol. 2009;44(1):66-70. doi: 10.1007/s00535-008-2271-9. Epub 2009 Jan 22.


Background: Inflammation induces some structural and biochemical alterations and oxidative damage in gastric tissue. In this study, we aimed to investigate the relationship among the severity of symptoms, oxidative stress, and grading scales of Helicobacter pylori-induced gastric inflammation in functional dyspepsia.

Methods: Thirty-five patients with functional dyspepsia were enrolled in the study. The severity of dyspepsia within the last 6 months was evaluated by Glasgow Dyspepsia Severity Score. In biopsy specimens of gastric mucosa, severity of gastritis was estimated by the revised Sydney Classification System, and oxidative stress parameters were studied.

Results: Although there was no statistically significant relationship between symptom scores and degree of chronic inflammation, a tendency for symptoms to be more severe has been observed in low levels of gastritis. Levels of sulfhydryl groups were lower in subjects with high levels of chronic inflammation, and Helicobacter pylori intensity (P < 0.001 and P = 0.02, respectively). Levels of malondialdehyde were higher in subjects with high levels of chronic inflammation (P = 0.04). There was a statistically significant but a weak positive correlation between symptom scores and sulfhydryl levels (P < 0.001, r = 0.323).

Conclusions: In conclusion, there may be an inverse relation between severity of symptoms and level of Helicobacter pylori induced gastric inflammation or oxidative stress in patients with functional dyspepsia.

MeSH terms

  • Adult
  • Aged
  • Dyspepsia / classification
  • Dyspepsia / microbiology
  • Dyspepsia / physiopathology*
  • Female
  • Gastric Mucosa / microbiology
  • Gastric Mucosa / pathology
  • Helicobacter Infections / microbiology
  • Helicobacter Infections / physiopathology*
  • Helicobacter pylori / isolation & purification
  • Humans
  • Inflammation / microbiology
  • Inflammation / physiopathology*
  • Male
  • Malondialdehyde / metabolism
  • Middle Aged
  • Oxidative Stress*
  • Severity of Illness Index
  • Sulfhydryl Compounds / metabolism
  • Young Adult


  • Sulfhydryl Compounds
  • Malondialdehyde