Laparoscopic pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy

Abstract

Background: Persistent hyperinsulinemic hypoglycemia of infancy (PHHI) is considered the most common cause of persistent neonatal hypoglycemia. Management of PHHI involves use of medical agents and its failure is an indication of surgical intervention. Traditionally, an open pancreatectomy was the standard of care but recently laparoscopic pancreatectomy was described. We report our experience with laparoscopic pancreatectomy for PHHI for the period from March 2004 to February 2008.

Methods: A retrospective chart review was conducted for patients managed for PHHI with laparoscopic pancreatectomy for that period. Demographic and clinical data were retrieved. Descriptive data were generated, and SPSS version 10 statistical package (SPSS, Chicago, Ill) was used.

Results: Twelve patients diagnosed with PHHI were managed with laparoscopic pancreatectomy for that period. Median age at procedure was 11.5 months (range, 0.5-89 months). Median extent of pancreatectomy was 90% (range, 85%-95%). There were 2 (16%) conversions to open technique. One patient (8%) required reoperation 3 months after the procedure. Patients were followed up for a median of 23.5 months (range, 3-48 months). Four (33%) were euglycemic with no medications. Three patients remained on octreotide postoperatively to be euglycemic, and 3 patients needed a combination of octreotide and diazoxide. One patient remained euglycemic for 10 months then started on octreotide because of recurrence of hypoglycemia. One patient remained hypoglycemic postoperatively and required reoperation 3 months later to control symptoms. He became diabetic 4 months after reoperation on insulin.

Conclusions: Our data suggest that laparoscopic pancreatectomy for medically unresponsive PHHI is feasible and safe. Longer follow-up is needed to ascertain effectiveness.