Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects

Diabetologia. 1991 Jul;34(7):483-7. doi: 10.1007/BF00403284.


Insulin responses to intravenous glucose infusion and glucose utilization during hyperinsulinaemic euglycaemic clamp were determined in a large homogeneous group of 65-year-old male subjects. Twenty-eight had untreated Type 2 (non-insulin-dependent) diabetes mellitus and the remaining 44 control subjects had a normal glucose tolerance. Diabetic patients with abdominal obesity displayed peripheral insulin resistance in combination with defective insulin secretion, whereas non-obese diabetic patients showed only a secretory defect. Thus, Type 2 diabetes in obese and non-obese elderly male subjects may take two forms where the cause of hyperglycaemia differs.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blood Glucose / metabolism
  • Body Weight
  • Diabetes Mellitus / etiology*
  • Diabetes Mellitus, Type 2 / etiology*
  • Glucose Tolerance Test
  • Humans
  • Insulin / blood
  • Insulin / metabolism*
  • Insulin Secretion
  • Male
  • Middle Aged
  • Obesity / physiopathology*
  • Reference Values


  • Blood Glucose
  • Insulin