N-->S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives

Org Lett. 2009 Feb 19;11(4):823-6. doi: 10.1021/ol8028093.

Abstract

N-->S acyl-transfer-mediated synthesis of peptide thioesters utilizing an N-aminoacyl-N-sulfanylethylaminobenzoic acid derivative has been examined. The developed synthetic methodology for peptide thioesters is compatible with Fmoc solid-phase peptide synthesis (SPPS).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anilides / chemistry*
  • Esters
  • Molecular Structure
  • Nitrogen / chemistry
  • Peptides / chemical synthesis*
  • Peptides / chemistry
  • Sulfur / chemistry

Substances

  • Anilides
  • Esters
  • Peptides
  • Sulfur
  • Nitrogen