Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation

Immunol Rev. 2008 Dec;226:219-33. doi: 10.1111/j.1600-065X.2008.00711.x.


Recent progress in our understanding of mechanisms by which the immunosuppressive cytokine interleukin-10 (IL-10) participates in an ever-increasing diversity of T-cell lineages to maintain immune homeostasis has broadened the framework for defining regulatory and effector T cells and has blurred the lines between them. In this review, we highlight established and emerging roles for IL-10 produced by distinct CD4(+) T-cell lineages that underlie its non-redundant role in curbing immune responses to the intestinal microbiota at steady state and its role to limit T-cell-driven inflammation in responses to pathogens.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytokines / immunology*
  • Cytokines / metabolism
  • Forkhead Transcription Factors / immunology*
  • Forkhead Transcription Factors / metabolism
  • Humans
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Interleukin-10 / immunology*
  • Interleukin-10 / metabolism
  • Intestines / immunology
  • Intestines / microbiology
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / metabolism
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / metabolism


  • Cytokines
  • Forkhead Transcription Factors
  • Interleukin-10