Abstract
Recent progress in our understanding of mechanisms by which the immunosuppressive cytokine interleukin-10 (IL-10) participates in an ever-increasing diversity of T-cell lineages to maintain immune homeostasis has broadened the framework for defining regulatory and effector T cells and has blurred the lines between them. In this review, we highlight established and emerging roles for IL-10 produced by distinct CD4(+) T-cell lineages that underlie its non-redundant role in curbing immune responses to the intestinal microbiota at steady state and its role to limit T-cell-driven inflammation in responses to pathogens.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cytokines / immunology*
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Cytokines / metabolism
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Forkhead Transcription Factors / immunology*
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Forkhead Transcription Factors / metabolism
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Humans
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Inflammation / immunology*
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Inflammation / metabolism
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Interleukin-10 / immunology*
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Interleukin-10 / metabolism
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Intestines / immunology
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Intestines / microbiology
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism
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T-Lymphocytes, Regulatory / immunology*
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T-Lymphocytes, Regulatory / metabolism
Substances
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Cytokines
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Forkhead Transcription Factors
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Interleukin-10