Ten years of rizatriptan: from development to clinical science and future directions

Headache. 2009 Feb:49 Suppl 1:S3-20. doi: 10.1111/j.1526-4610.2008.01335.x.

Abstract

The year 2008 marked the 10th anniversary since rizatriptan was first launched for the acute treatment of migraine. In this article we discuss the concepts that motivated the preclinical and clinical development of rizatriptan, the clinical evidence that has driven its use over the past decade, rizatriptan's overall contribution to the field, and future directions for research.

Publication types

  • Historical Article
  • Meta-Analysis
  • Review

MeSH terms

  • Animals
  • Drug Design
  • Drug Evaluation / trends
  • Drug Therapy / trends
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Migraine Disorders / drug therapy*
  • Migraine Disorders / history
  • Randomized Controlled Trials as Topic
  • Serotonin Receptor Agonists* / history
  • Serotonin Receptor Agonists* / pharmacology
  • Serotonin Receptor Agonists* / therapeutic use
  • Triazoles* / history
  • Triazoles* / pharmacology
  • Triazoles* / therapeutic use
  • Tryptamines* / history
  • Tryptamines* / pharmacology
  • Tryptamines* / therapeutic use

Substances

  • Serotonin Receptor Agonists
  • Triazoles
  • Tryptamines
  • rizatriptan