Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 36 (1), 27-42

Iron Therapy for Preterm Infants


Iron Therapy for Preterm Infants

Raghavendra Rao et al. Clin Perinatol.


Preterm infants are at risk for both iron deficiency and iron overload. The role of iron in multiple organ functions suggests that iron supplementation is essential for the preterm infant. Conversely, the potential for iron overload and the poorly developed antioxidant measures in the preterm infant argue against indiscriminate iron supplementation in this population. This article reviews the predisposing factors and consequences of iron deficiency and iron overload in the preterm infant, discusses the current recommendation for iron supplementation and its appropriateness, and describes potential management strategies that strike a balance between iron deficiency and iron toxicity.

Similar articles

  • Neonatal Iron Nutrition
    R Rao et al. Semin Neonatol 6 (5), 425-35. PMID 11988032.
    Preterm infants are prone to iron deficiency. Their total body iron content at birth is low and gets further depleted by clinical practices such as uncompensated phleboto …
  • Perinatal Aspects of Iron Metabolism
    R Rao et al. Acta Paediatr Suppl 91 (438), 124-9. PMID 12477276. - Review
    The highly variable iron status of preterm infants combined with their risk for iron deficiency and toxicity warrants careful monitoring and support in the newborn and po …
  • Efficacy of Supplementation With Iron Sulfate Compared to Iron Bisglycinate Chelate in Preterm Infants
    R Bagna et al. Curr Pediatr Rev 14 (2), 123-129. PMID 29366419.
    The higher bioavailability of iron bisglycinate chelate resulted in a lower load of elemental iron, a quarter of the dose, and achieved equivalent efficacy compared to ir …
  • Iron Deficiency Anemia in Late-Preterm Infants
    H Ozdemir et al. Turk J Pediatr 55 (5), 500-5. PMID 24382530.
    Iron deficiency anemia is a common problem in newborn infants. The American Academy of Pediatrics recommends iron prophylaxis at 4 months of age for term infants. There i …
  • Iron in Fetal and Neonatal Nutrition
    R Rao et al. Semin Fetal Neonatal Med 12 (1), 54-63. PMID 17157088. - Review
    Both iron deficiency and iron excess during the fetal and neonatal period bode poorly for developing organ systems. Maternal conditions such as iron deficiency, diabetes …
See all similar articles

Cited by 24 PubMed Central articles

See all "Cited by" articles

Publication types