ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells

FEBS Lett. 2009 Feb 4;583(3):568-72. doi: 10.1016/j.febslet.2008.12.063. Epub 2009 Jan 20.


ZFAT (also known as ZNF406), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc-finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT-4 cells. Intriguing is that mouse ZFAT expression in CD4(+) lymphocytes is increased during blast formation. Furthermore, ZFAT-knockdown in MOLT-4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis* / drug effects
  • Caspase Inhibitors
  • Caspases / metabolism
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Enzyme Activation
  • Humans
  • Mice
  • Protease Inhibitors / pharmacology
  • RNA, Small Interfering / genetics
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*


  • Caspase Inhibitors
  • Protease Inhibitors
  • RNA, Small Interfering
  • Transcription Factors
  • ZFAT protein, human
  • Caspases