Insights into the cellular role of enigmatic DNA polymerase iota

DNA Repair (Amst). 2009 Mar 1;8(3):420-3. doi: 10.1016/j.dnarep.2008.12.007. Epub 2009 Jan 21.

Abstract

It has been a decade since the discovery of human DNA polymerase iota (poliota). Since that time, the enzyme has been characterized extensively at the biochemical level, but the cellular function of poliota remains enigmatic. Recent studies on poliota have, however, provided much needed insights into its biological role(s) and suggest that the enzyme plays important functions in protecting humans from the deleterious consequences of exposure to both oxidative- and ultraviolet light-induced DNA damage.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA / metabolism
  • DNA / radiation effects
  • DNA Damage
  • DNA Repair
  • DNA-Directed DNA Polymerase / physiology*
  • Humans
  • Mice
  • Oxidative Stress / genetics
  • Proliferating Cell Nuclear Antigen / metabolism
  • Sarcoma / genetics
  • Sarcoma / metabolism
  • Skin Neoplasms / genetics
  • Skin Neoplasms / metabolism
  • Substrate Specificity
  • Ultraviolet Rays / adverse effects

Substances

  • Proliferating Cell Nuclear Antigen
  • DNA
  • DNA polymerase iota
  • DNA-Directed DNA Polymerase