Abstract
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration. This brief review provides a historic account of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis.
Publication types
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Historical Article
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Review
MeSH terms
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Angiogenesis Inhibitors / pharmacology
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Animals
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Endothelial Cells / metabolism
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History, 20th Century
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History, 21st Century
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Humans
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Neoplasms / blood supply
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Neoplasms / drug therapy
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Neovascularization, Physiologic* / drug effects
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Receptors, Vascular Endothelial Growth Factor / metabolism
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Signal Transduction* / drug effects
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Vascular Endothelial Growth Factor A / antagonists & inhibitors
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Vascular Endothelial Growth Factor A / history
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Vascular Endothelial Growth Factor A / metabolism*
Substances
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Angiogenesis Inhibitors
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Vascular Endothelial Growth Factor A
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Receptors, Vascular Endothelial Growth Factor