Neuroprotective protein and carboxypeptidase E

J Mol Neurosci. 2009 Sep;39(1-2):1-8. doi: 10.1007/s12031-008-9164-5. Epub 2009 Jan 23.

Abstract

This review outlines the neuroprotective activities and structural specificities of two distinct proteins, activity-dependent neuroprotective protein, a protein assigned transcription factor/chromatin remodeling activity, and carboxypeptidase E, a classic exopeptidase. Future studies will elucidate how these two versatile proteins converge onto a similar endpoint: neuroprotection.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Brain / cytology
  • Brain / metabolism
  • Carboxypeptidase H / genetics
  • Carboxypeptidase H / metabolism*
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism*
  • Humans
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism*
  • Neurons / cytology
  • Neurons / metabolism
  • Neuroprotective Agents / metabolism*
  • Reactive Oxygen Species / metabolism

Substances

  • Adnp protein, mouse
  • Homeodomain Proteins
  • Nerve Tissue Proteins
  • Neuroprotective Agents
  • Reactive Oxygen Species
  • Carboxypeptidase H