Genetic thrombophilia variants and risk for preeclampsia among American Indians

Hypertens Pregnancy. 2009 Feb;28(1):85-94. doi: 10.1080/10641950802419887.


Objective: To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia.

Methods: A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms.

Results: The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found.

Conclusion: The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Factor V / genetics
  • Female
  • Genotype
  • Humans
  • Indians, North American / genetics*
  • Pre-Eclampsia / ethnology
  • Pre-Eclampsia / genetics*
  • Pregnancy
  • Prospective Studies
  • Prothrombin / genetics
  • Risk Factors
  • Thrombophilia / complications
  • Thrombophilia / genetics*
  • Young Adult


  • factor V Leiden
  • Factor V
  • Prothrombin