Genetic Variants Near TNFAIP3 on 6q23 Are Associated With Systemic Lupus Erythematosus

Nat Genet. 2008 Sep;40(9):1059-61. doi: 10.1038/ng.200.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / genetics
  • Chromosomes, Human, Pair 6*
  • DNA-Binding Proteins
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics*
  • Lupus Erythematosus, Systemic / genetics*
  • Nuclear Proteins / genetics*
  • Polymorphism, Single Nucleotide
  • Tumor Necrosis Factor alpha-Induced Protein 3

Substances

  • DNA-Binding Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • TNFAIP3 protein, human
  • Tumor Necrosis Factor alpha-Induced Protein 3

Grant support