Continuing growth of rate of detection of primary tumors of the heart has been noted recently. Prevalence of cardiac tumors in European population according to data of different authors varies from 25 to 5500 cases per 1 million of autopsies. Malignant mesothelioma belongs to most rarely met tumors. In most cases pericardial malignant mesothelioma possesses high secretory capacity what allows to suspect tumorous process in hemorrhagic pericarditis with recurrences after repetitive punctures. The paper contains description of a patient with malignant pericardial mesothelioma. Special feature of this case has been atypical clinical course of the disease complicated by development of acute myocardial infarction of posterior left ventricular wall.