Primary leiomyosarcoma of bone

Histopathology. 1991 Sep;19(3):257-62. doi: 10.1111/j.1365-2559.1991.tb00031.x.


Four cases of primary leiomyosarcoma of bone are presented. The histology of this rare tumour has been studied with a panel of monoclonal antibodies to the intermediate filaments desmin and vimentin, and to other markers including smooth muscle actin, myosin, alpha 1-antitrypsin, alpha 1-antichymotrypsin, lysozyme, S-100 protein and cytokeratin. The tumour cells were uniformly positive for desmin, vimentin, and in one case for smooth muscle actin; all the other markers were negative. The findings have been compared with other spindle cell lesions of bone and with electron-microscopy of the tumours. Immunohistochemistry allows the histological diagnosis to be made without the need to resort to ultrastructural studies.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Aged, 80 and over
  • Biomarkers
  • Bone Neoplasms / chemistry
  • Bone Neoplasms / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Leiomyosarcoma / chemistry
  • Leiomyosarcoma / pathology*
  • Male
  • Middle Aged


  • Biomarkers