The macrophage migration inhibitory factor (MIF) gene polymorphism in Czech and Russian patients with myocardial infarction

Clin Chim Acta. 2009 Apr;402(1-2):199-202. doi: 10.1016/j.cca.2008.12.034. Epub 2009 Jan 9.


Background: Macrophage migration inhibitory factor (MIF) is a cytokine implicated in early and advanced atherosclerosis. The aim of this study was to investigate whether polymorphism of MIF gene is associated with myocardial infarction (MI).

Methods: Single nucleotide polymorphism (SNP) in MIF gene (-173G/C, rs755622) was investigated in Czech (n=219) and Russian (n=240) MI patients and population control from the same geographical areas (Czech, n=137; Russian, n=174). Further, another SNP (rs1007888) located within the 3' flanking region of the MIF gene was investigated in Czech MI patients and control subjects.

Results: There were no significant differences in the distribution of MIF -173G/C genotypes, alleles or carriage rates between case and control groups in either populations. However, the GG genotype of the MIF SNP rs1007888 was associated with MI in Czech female patients (p=0.027).

Conclusions: Taken together with previous reports, our study suggests that particular MIF gene polymorphisms may contribute to MI susceptibility in females.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Czech Republic / epidemiology
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Intramolecular Oxidoreductases / genetics*
  • Macrophage Migration-Inhibitory Factors / genetics*
  • Male
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Myocardial Infarction / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Russia / epidemiology
  • Sex Factors


  • Macrophage Migration-Inhibitory Factors
  • Intramolecular Oxidoreductases
  • MIF protein, human