Role of estrogen receptor alpha in membrane-initiated signaling in neural cells: interaction with IGF-1 receptor

J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):2-7. doi: 10.1016/j.jsbmb.2008.12.014. Epub 2009 Jan 9.


The mechanisms of action of estradiol in the nervous system involve nuclear-initiated steroid signaling and membrane-initiated steroid signaling. Estrogen receptors (ERs) are involved in both mechanisms. ERalpha interacts with the signaling of IGF-1 receptor in neural cells: ERalpha transcriptional activity is regulated by IGF-1 receptor signaling and estradiol regulates IGF-1 receptor signaling. The interaction between ERalpha and the IGF-1 receptor in the brain may occur at the plasma membrane of neurons and glial cells. Caveolin-1 may provide the scaffolding for the interaction of different membrane-associated molecules, including voltage-dependent anion channel, ERalpha and IGF-I receptor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism
  • Cell Membrane / metabolism
  • Estrogen Receptor alpha / metabolism*
  • Neurons / cytology
  • Neurons / metabolism*
  • Receptor, IGF Type 1 / metabolism*
  • Signal Transduction / physiology*


  • Estrogen Receptor alpha
  • Receptor, IGF Type 1