Altering the chromatin landscape for nucleotide excision repair

Mutat Res. Jul-Aug 2009;682(1):13-20. doi: 10.1016/j.mrrev.2009.01.002. Epub 2009 Jan 9.

Abstract

DNA acts as a 'workbench' for various nuclear processes that occur inside living cells. In eukaryotic cells, DNA is highly compacted in a structural hierarchy with histones and other proteins into chromatin. This compaction affects DNA structure and coordinates the accessibility to site-specific nuclear factors during DNA processing events. DNA repair is no exception to this general rule and several reviews have appeared recently that discuss this topic in detail [1-3]. Here, we focus on recent findings correlating changes in DNA repair with subtle variations in the chromatin landscape.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Chromatin / metabolism
  • Chromatin Assembly and Disassembly*
  • DNA Damage
  • DNA Repair*
  • Histones / metabolism
  • Humans
  • Models, Genetic
  • Models, Molecular
  • Mutation

Substances

  • Chromatin
  • Histones
  • Adenosine Triphosphate