Nataxazole, a new benzoxazole derivative with antitumor activity produced by Streptomyces sp. Tü 6176

Patricia S M Sommer; Rosemary C Almeida; Kathrin Schneider; Winfried Beil; Roderich D Süssmuth; Hans-Peter Fiedler

doi:10.1038/ja.2008.97

Nataxazole, a new benzoxazole derivative with antitumor activity produced by Streptomyces sp. Tü 6176

J Antibiot (Tokyo). 2008 Nov;61(11):683-6. doi: 10.1038/ja.2008.97.

Authors

Patricia S M Sommer¹, Rosemary C Almeida, Kathrin Schneider, Winfried Beil, Roderich D Süssmuth, Hans-Peter Fiedler

Affiliation

¹ Centro de Biociencias, Universidade Federal do Rio Grande do Norte, Natal, Brasil.

PMID: 19168984
DOI: 10.1038/ja.2008.97

Abstract

The new benzoxazole derivative nataxazole was isolated from Streptomyces sp. (strain Tü 6176). Nataxazole is related in structure to the potent antitumor compounds UK-1 and AJI9561 and showed similar strong growth inhibitory activity against various human tumor cell lines.

MeSH terms

Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Benzoxazoles / chemistry
Benzoxazoles / isolation & purification
Benzoxazoles / pharmacology*
Cell Line, Tumor
Humans
Molecular Structure
Streptomyces / chemistry
Streptomyces / metabolism*

Substances

Antineoplastic Agents
Benzoxazoles
nataxazole