Psoriasis Genome-Wide Association Study Identifies Susceptibility Variants Within LCE Gene Cluster at 1q21

Nat Genet. 2009 Feb;41(2):205-10. doi: 10.1038/ng.310. Epub 2009 Jan 25.

Abstract

We report the first large genome-wide association study (GWAS) in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design. In the first stage, we carried out a genome-wide association analysis in 1,139 cases and 1,132 controls of Chinese Han ancestry using Illumina Human 610-Quad BeadChips. In the second stage, we took top SNPs forward for replication in two independent samples of 5,182 cases and 6,516 controls of Chinese Han ancestry, and 539 cases and 824 controls of Chinese Uygur ancestry. In addition to the strong replication for two known susceptibility loci MHC (rs1265181, P = 1.93 x 10(-208), OR = 22.62) and IL12B (rs3213094, P(combined) = 2.58 x 10(-26), OR = 0.78), we identified a new susceptibility locus within the LCE gene cluster on 1q21 (rs4085613, P(combined) = 6.69 x 10(-30), OR = 0.76).

Publication types

  • Research Support, Non-U.S. Gov't
  • Validation Study

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Child
  • Chromosomes, Human, Pair 1*
  • Cornified Envelope Proline-Rich Proteins / genetics*
  • Female
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Humans
  • Interleukin-12 Subunit p40 / genetics
  • Linkage Disequilibrium
  • Major Histocompatibility Complex / genetics
  • Male
  • Middle Aged
  • Multigene Family
  • Polymorphism, Single Nucleotide
  • Psoriasis / genetics*
  • Young Adult

Substances

  • Cornified Envelope Proline-Rich Proteins
  • IL12B protein, human
  • Interleukin-12 Subunit p40