Challenging the gold standard: should mannitol remain our first-line defense against intracranial hypertension?

J Neurosci Nurs. 2008 Dec;40(6):362-8.


Mannitol has long been the "gold standard" for treatment of cerebral edema and refractory intracranial hypertension in traumatic brain injury, subarachnoid hemorrhage, and stroke. Studies performed in animals have shown that hypertonic saline (HS), in doses ranging from 3% to 10%, may be more effective than mannitol in treating these populations. Recently, randomized clinical trials have evaluated the efficacy and safety of HS versus mannitol in the treatment of elevated intracranial pressure (ICP). This research has been prompted by mounting concern about the side effects of mannitol, the limited ability to give multiple doses of the drug, and an increased understanding of cerebral physiology. Four studies have compared the use of HS and mannitol in brain-injured populations. These studies have shown that not only is HS a safe drug (no patients experienced adverse effects), it is also more efficient in reducing ICP. Efficiency is defined as the drug's ability to decrease ICP to acceptable levels and to maintain lower ICPs for a longer duration of time. It is important for nurses who administer osmotic diuretics to evaluate and understand the current research to provide educated and appropriate care.

Publication types

  • Review

MeSH terms

  • Cerebrovascular Circulation / drug effects
  • Diuretics, Osmotic / adverse effects
  • Diuretics, Osmotic / therapeutic use*
  • Evidence-Based Practice
  • Hemodynamics / drug effects
  • Humans
  • Intracranial Hypertension / drug therapy*
  • Intracranial Hypertension / metabolism
  • Intracranial Hypertension / nursing
  • Intracranial Hypertension / physiopathology
  • Intracranial Pressure / drug effects
  • Mannitol / adverse effects
  • Mannitol / therapeutic use*
  • Nurse's Role
  • Osmolar Concentration
  • Randomized Controlled Trials as Topic
  • Research Design
  • Safety
  • Saline Solution, Hypertonic / therapeutic use*
  • Sodium / blood
  • Treatment Outcome


  • Diuretics, Osmotic
  • Saline Solution, Hypertonic
  • Mannitol
  • Sodium