Abstract
A concise synthesis of (+/-)-rhazinal that hinges on novel oxidative Heck cyclizations and palladium-catalyzed direct couplings is described. An X-ray structure of N-MOM-rhazinal, which provides insight into the conformation of the strained 9-membered lactam ring, is described.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemical synthesis*
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Aldehydes / chemistry
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Amides / chemistry
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Catalysis
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Cyclization
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Indolizines / chemical synthesis*
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Indolizines / chemistry
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Oxidation-Reduction
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Palladium / chemistry*
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Pyrroles / chemistry
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Stereoisomerism
Substances
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Aldehydes
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Amides
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Indolizines
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Pyrroles
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rhazinal
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indolizine
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Palladium