Abstract
Inhibitors of phenylethanolamine N-methyltransferase [PNMT, the enzyme that catalyzes the final step in the biosynthesis of epinephrine (Epi)] may be of use in determining the role of Epi in the central nervous system. Here we describe the synthesis and characterization of 7-SCN tetrahydroisoquinoline as an affinity label for human PNMT.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Epinephrine / metabolism
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Epinephrine / physiology
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Humans
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Phenylethanolamine N-Methyltransferase / antagonists & inhibitors
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Phenylethanolamine N-Methyltransferase / metabolism*
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Rats
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Tetrahydroisoquinolines / chemical synthesis*
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Tetrahydroisoquinolines / chemistry
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Tetrahydroisoquinolines / pharmacology*
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Time Factors
Substances
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7-isothiocyanatotetrahydroisoquinoline
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Tetrahydroisoquinolines
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Phenylethanolamine N-Methyltransferase
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Epinephrine