Keratinocyte-melanocyte graft technique followed by PUVA therapy for stable vitiligo

Indian J Dermatol Venereol Leprol. 2008 Nov-Dec;74(6):622-4. doi: 10.4103/0378-6323.45106.

Abstract

Background: Various surgical procedures for correcting stable vitiligo exist but these have their own limitations. Autologous, non-cultured, non-trypsinized, melanocyte plus keratinocyte grafting is a new and simple method of vitiligo surgery.

Objective: The study aimed to evaluate efficacy of a new grafting technique in vitiligo patches.

Methods: Eighteen vitiligo patches underwent this procedure. The upper layer of epidermis was removed by superficial dermabrasion using a dermabrader micromotor until the epidermis appeared wet and shiny. Then, antibiotic ointment was applied and dermabrasion was continued up to the whitish area of the upper dermis. The paste-like material (ointment with entangled epidermal particles) was collected and spread over the dermabraded recipient site.

Results: Pigmentation usually started at 4-6 weeks. Complete uniform pigmentation took 16-20 weeks.

Conclusion: For smaller vitiligo patches this method gives cosmetically acceptable results. It is easy to perform and does not require specific laboratory setup.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / administration & dosage
  • Dermabrasion / methods
  • Female
  • Humans
  • Keratinocytes / transplantation*
  • Male
  • Melanocytes / transplantation*
  • PUVA Therapy* / methods
  • Skin Transplantation / methods*
  • Vitiligo / drug therapy
  • Vitiligo / pathology
  • Vitiligo / surgery*
  • Young Adult

Substances

  • Anti-Bacterial Agents