SHV-28, an extended-spectrum beta-lactamase produced by a clinical isolate of Klebsiella pneumoniae in south India

Indian J Med Microbiol. 2009 Jan-Mar;27(1):51-4.

Abstract

SHV-28, an extended spectrum beta-lactamase from a clinical isolate of Klebsiella pneumoniae , had an isoelectric point of 7.6 and a substrate profile showing preferential hydrolysis for cefotaxime over ceftazidime. It differed from SHV-1 by one amino acid substitution. The conserved S-T-F-K and K-T-G motifs were identified by SHV-28 protein sequencing.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Amino Acid Sequence
  • Amino Acid Substitution / genetics
  • Bacterial Proteins / biosynthesis*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Base Sequence
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • Humans
  • India
  • Isoelectric Point
  • Klebsiella Infections / microbiology*
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / enzymology*
  • Male
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • Substrate Specificity
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / chemistry
  • beta-Lactamases / genetics
  • beta-Lactams / metabolism

Substances

  • Bacterial Proteins
  • DNA, Bacterial
  • beta-Lactams
  • beta-Lactamases

Associated data

  • GENBANK/AF299299