In vivo anti-malarial effect of the beta-amino alcohol 1t on Plasmodium berghei

Parasitol Res. 2009 Jun;104(6):1459-64. doi: 10.1007/s00436-009-1348-6. Epub 2009 Jan 27.


Glycerol derivatives are a class of compounds, which are easy and inexpensive to produce with potent anti-malarial activities against blood stages of Plasmodium falciparum in vitro. In the present study, one of these compounds, termed 1t, which had the lowest IC(50) values, was assessed in a murine malarial model. Nuclear magnetic resonance imaging and Balb/c mice infected with Plasmodium berghei ANKA strain were treated in a 4-day suppressive test. Mice received a once-daily intraperitoneal administration of 50 mg/Kg of the drug for 4 days. Although no parasitaemia clearance was reached, a slower parasite proliferation and a slightly longer survival time compared with the placebo group were observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Alcohols / administration & dosage
  • Amino Alcohols / pharmacology
  • Amino Alcohols / therapeutic use*
  • Animals
  • Antimalarials / administration & dosage
  • Antimalarials / pharmacology
  • Antimalarials / therapeutic use*
  • Female
  • Inhibitory Concentration 50
  • Injections, Intraperitoneal
  • Malaria / drug therapy*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Parasitemia / drug therapy
  • Plasmodium berghei / drug effects*
  • Survival Analysis


  • Amino Alcohols
  • Antimalarials