Published international classification of retinoblastoma (ICRB) definitions contain inconsistencies--an analysis of impact

Ophthalmic Genet. 2009 Mar;30(1):40-4. doi: 10.1080/13816810802452168.


Purpose: To determine the impact of subtle differences (most notably in their classification of group E eyes) in two published versions of the ICRB (Philadelphia and the Children's Hospital Los Angeles).

Methods: Analysis of a series of 96 eyes with intra-ocular retinoblastoma.

Results: The disparate criteria of the 2 published ICRB schemas affected group assignment of 5.2% of the eyes (25% of the group E eyes).

Conclusion: Discrepancies need to be reconciled to ensure accurate and uniform application of the ICRB.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Carboplatin / therapeutic use
  • Child, Preschool
  • Humans
  • Infant
  • International Classification of Diseases / standards*
  • Publications / standards
  • Retinal Neoplasms / classification*
  • Retinal Neoplasms / drug therapy
  • Retinal Neoplasms / mortality
  • Retinoblastoma / classification*
  • Retinoblastoma / drug therapy
  • Retinoblastoma / mortality
  • Survival Rate


  • Antineoplastic Agents
  • Carboplatin