Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution

Phytother Res. 2009 Jun;23(6):775-7. doi: 10.1002/ptr.2651.


The degree of absorption of bioflavonoids, a diverse and complex group of plant derived phytonutrients, has been a frequent debate among scientists. Monomeric flavonoid species are known to be absorbed within 2 h. The kinetics of plasma reactive oxygen species, a reflection of bioactivity, of a commercial blend of flavonoids, OPC-3 was investigated. OPC-3 was selected to compare absorption of an isotonic flavonoid solution vs tablet form with the equivalent amount of fluid. In the case of isotonic OPC-3 the reactive oxygen species of the subject's plasma decreased significantly (p < 0.05), six times greater than OPC-3 tablets by 10 min post-consumption. After 20 min the isotonic formulation was approximately four times more bioavailable and after 40 min twice as bioavailable as the tablet, respectively. At time points 1 h and later, both isotonic and tablet formulations lowered oxidative stress, although the isotonic formulation values remained significantly better throughout the investigation period of 4 h. These findings point to a dramatically accelerated bioavailability of flavonoids delivered in an isotonic formulation.

MeSH terms

  • Adult
  • Antioxidants / administration & dosage*
  • Antioxidants / pharmacokinetics*
  • Biological Availability
  • Female
  • Flavonoids / administration & dosage*
  • Flavonoids / pharmacokinetics*
  • Humans
  • Isotonic Solutions
  • Male
  • Oxidative Stress / drug effects
  • Reactive Oxygen Species / blood
  • Tablets


  • Antioxidants
  • Flavonoids
  • Isotonic Solutions
  • Reactive Oxygen Species
  • Tablets