Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 8 (9), 726-36

Mesenchymal Stem Cells in Health and Disease


Mesenchymal Stem Cells in Health and Disease

Antonio Uccelli et al. Nat Rev Immunol.


Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues. They can differentiate into cells of the mesodermal lineage, such as adipocytes, osteocytes and chondrocytes, as well as cells of other embryonic lineages. MSCs can interact with cells of both the innate and adaptive immune systems, leading to the modulation of several effector functions. After in vivo administration, MSCs induce peripheral tolerance and migrate to injured tissues, where they can inhibit the release of pro-inflammatory cytokines and promote the survival of damaged cells. This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches.

Similar articles

  • Trafficking and Differentiation of Mesenchymal Stem Cells
    ZJ Liu et al. J Cell Biochem 106 (6), 984-91. PMID 19229871. - Review
    Mesenchymal stem cells (MSCs) are a heterogeneous population of stem/progenitor cells with pluripotent capacity to differentiate into mesodermal and non-mesodermal cell l …
  • When Stem Cells Meet Immunoregulation
    R Tasso et al. Int Immunopharmacol 9 (5), 596-8. PMID 19539568. - Review
    The clinical use of stem cells to prevent tissue injury or reconstruct damaged organs is constrained by different ethical and biological issues. Whereas the use of adult …
  • Multipotent Mesenchymal Stromal Cell Therapy in Renal Disease and Kidney Transplantation
    ME Reinders et al. Nephrol Dial Transplant 25 (1), 17-24. PMID 19861311. - Review
    Cell therapies aim at differentiation of stem cells into the specific cell type required to repair damaged or destroyed cells or tissues. Over recent years, cell therapy …
  • Mesenchymal Stem Cells and Their Potential as Cardiac Therapeutics
    MF Pittenger et al. Circ Res 95 (1), 9-20. PMID 15242981. - Review
    Mesenchymal stem cells (MSCs) represent a stem cell population present in adult tissues that can be isolated, expanded in culture, and characterized in vitro and in vivo. …
  • Mesenchymal Stromal Cells
    ME Bernardo et al. Ann N Y Acad Sci 1176, 101-17. PMID 19796238. - Review
    Mesenchymal stromal cells (MSCs) are multipotent cells that can be isolated from several human tissues and expanded ex vivo for clinical use. MSCs are identified by their …
See all similar articles

Cited by 969 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources