General method for rapid synthesis of multicomponent peptide mixtures

Int J Pept Protein Res. 1991 Jun;37(6):487-93. doi: 10.1111/j.1399-3011.1991.tb00765.x.


A method is suggested for the synthesis of multicomponent peptide mixtures. The method is a solid phase synthesis modified in order to give a closely equimolar mixture of peptides with predetermined sequences. The main point of modification is that before every coupling cycle the resin is divided into equal parts and each portion is coupled with a different amino acid. Then the portion are mixed and before the next coupling cycle the resin is again distributed into equal portions. The method is illustrated by the synthesis of a mixture of 27 tetrapeptides and that of 180 pentapeptides.

MeSH terms

  • Amino Acid Sequence
  • Chromatography, High Pressure Liquid
  • Electrophoresis, Paper
  • Molecular Sequence Data
  • Peptide Mapping
  • Peptides / chemical synthesis*
  • Peptides / isolation & purification


  • Peptides