Near-IR remote release from assemblies of liposomes and nanoparticles

Angew Chem Int Ed Engl. 2009;48(10):1807-9. doi: 10.1002/anie.200805572.

Abstract

Set free by light: Near-IR (NIR) laser-initiated remote release of fluorescent dye from complexes of liposome-gold-nanoparticle aggregates is demonstrated (see fluorescence images). Complexes of the desired size are shown to be a viable approach to the construction of vesicle-based drug-delivery systems with light-triggered remote release characteristics. This opens up a new method to manipulate liposome-based drug-delivery systems in a biocompatible way by using the near-IR spectral range.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Carriers / chemistry*
  • Drug Delivery Systems / methods
  • Fluorescent Dyes / chemistry
  • Fluorescent Dyes / radiation effects
  • Gold / chemistry*
  • Lasers*
  • Liposomes / chemistry*
  • Liposomes / radiation effects
  • Metal Nanoparticles / chemistry*
  • Microscopy, Electron, Transmission

Substances

  • Drug Carriers
  • Fluorescent Dyes
  • Liposomes
  • Gold