[HIV-1 genetic variability in non Spaniard infected children]

An Pediatr (Barc). 2009 Jan;70(1):20-6. doi: 10.1016/j.anpedi.2008.08.002. Epub 2008 Nov 11.
[Article in Spanish]


Introduction: The prevalence of HIV-1 non-B subtypes (HIV-NBS) is increasing in Europe, because of emigration from countries where genetic variants are endemic. Although HIV-NBS could have a different clinical evolution and could respond differently to antiretrovirals (AR) than B-subtypes, these variant's response remain undocumented.

Aims: To identify HIV-1 genetic variants and to determine clinical evolution in a non-Spaniard children infected with HIV-1.

Patients and method: Children with HIV-1 infection from endemic countries were tested for HIV-1 subtypes between 1-1-1988 and 31-12-2006. Twelve children less than 18 years old and born abroad were selected.

Results: HIV-NBS were isolated in 5 children (42%): CRF2_AG recombinant in 3 cases (Equatorial Guinea), Subtype C in one (Equatorial Guinea) and CRF13_cpx in last one (India).

Discussion: Because of the increasing frequency of patients with HIV-NBS and their unknown long-term evolution, all children from endemic countries should be tested for HIV subtypes. We believe new studies with more patients during longer times could reveal differences in these patient's clinical, immunological and virological evolution.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Genetic Variation*
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • Humans
  • Infant
  • Male
  • Retrospective Studies
  • Transients and Migrants*