Abstract
How is the chromosome segregation machinery modified to segregate homologs during meiosis I? The Dbf4-dependent Cdc7 kinase (DDK) has now been identified as a key regulator in this process.
MeSH terms
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / metabolism*
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Chromosome Segregation
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DNA Replication*
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Humans
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Meiosis / physiology*
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae / metabolism
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Saccharomyces cerevisiae Proteins / genetics
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Saccharomyces cerevisiae Proteins / metabolism
Substances
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Cell Cycle Proteins
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MCM5 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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CDC7 protein, human
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Protein Serine-Threonine Kinases