Meiosis: DDK is not just for replication

Curr Biol. 2009 Jan 27;19(2):R74-6. doi: 10.1016/j.cub.2008.12.003.

Abstract

How is the chromosome segregation machinery modified to segregate homologs during meiosis I? The Dbf4-dependent Cdc7 kinase (DDK) has now been identified as a key regulator in this process.

MeSH terms

  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Chromosome Segregation
  • DNA Replication*
  • Humans
  • Meiosis / physiology*
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism

Substances

  • Cell Cycle Proteins
  • MCM5 protein, S cerevisiae
  • Saccharomyces cerevisiae Proteins
  • CDC7 protein, human
  • Protein-Serine-Threonine Kinases