The 2006-2007 New York State (NYS) Hospital Laboratory Drill Series was implemented in order to test notification, referral and packaging and shipping (P&S) procedures at acute care hospital facilities (statewide, excluding New York City) that submit suspect bioterrorism (BT), chemical terrorism (CT), and/or pandemic influenza (Pan Flu) clinical specimens to the NYS Department of Health (DOH) Wadsworth Center for confirmatory testing. Results showed that 97% and 84% of hospital facilities had the ability to directly access the notification network and retrieve drill guidance, respectively. Most hospital laboratories (92%) demonstrated the ability to refer specimens to the Wadsworth Center laboratory. Evaluation of specimen submissions found that 68% of BT packages, 27% of Pan Flu packages, and 20% of CT packages arrived to the laboratory with no P&S deficiencies. It can be concluded that acute care hospital facilities in NYS are more prepared to refer and submit clinical specimens during a BT public health emergency than during a Pan Flu or CT emergency event.