The in vivo release of 90Y from cyclic and acyclic ligand-antibody conjugates

Int J Rad Appl Instrum B. 1991;18(5):469-76. doi: 10.1016/0883-2897(91)90107-v.


Yttrium binding ligands DOTA, caDTPA and CT-DTPA were each conjugated to monoclonal antibody B72.3, labelled with 90Y and injected into mice in order to assess the in vivo inertness of the antibody-linked 90Y-ligand complexes. Levels of 90Y in femur shafts of the DOTA-B72.3 mice were low, being approximately 7 and 44%, respectively, of levels in the femur shafts of the caDTPA-B72.3 and CT-DTPA-B72.3 treated mice. This finding demonstrates the greater inertness and by implication the greater suitability for immunotherapy of the DOTA-90Y complex.

MeSH terms

  • Animals
  • Antibodies, Monoclonal* / chemistry
  • Bone Marrow / metabolism
  • Bone and Bones / metabolism
  • Heterocyclic Compounds / pharmacokinetics
  • Heterocyclic Compounds, 1-Ring*
  • Immunoglobulin G / immunology
  • Isotope Labeling
  • Ligands
  • Male
  • Mice
  • Mice, Inbred Strains
  • Pentetic Acid / chemistry
  • Yttrium Radioisotopes / pharmacokinetics*


  • Antibodies, Monoclonal
  • Heterocyclic Compounds
  • Heterocyclic Compounds, 1-Ring
  • Immunoglobulin G
  • Ligands
  • Yttrium Radioisotopes
  • 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid
  • Pentetic Acid