Hyponatremia complicating labour--rare or unrecognised? A prospective observational study

BJOG. 2009 Mar;116(4):552-61. doi: 10.1111/j.1471-0528.2008.02063.x. Epub 2009 Jan 27.


Objective: The aim of this study was to investigate the occurrence of hyponatraemia following delivery, with a hypothesis that hyponatraemia has a high prevalence in labouring women.

Design: Prospective observational study.

Setting: Consultant-led delivery suite in County Hospital, Kalmar, Sweden.

Sample: A total of 287 pregnant women at term (37 full gestational weeks).

Methods: Oral fluids were allowed during labour. Blood samples were collected on admission, after delivery, and from the umbilical artery and vein.

Main outcome measure: Hyponatraemia defined as plasma sodium < or =130 mmol/l after delivery.

Results: Hyponatraemia was found in 16 (26%) of the 61 mothers who received more than 2500 ml of fluid during labour. Two-thirds of fluids were orally ingested. Decrease in plasma sodium concentration during labour correlated with duration of labour and the total fluid volume administered. Analysis by multivariate logistic regression showed that hyponatraemia was significantly correlated with fluid volume (P < 0.001) but not with oxytocin administration or epidural analgesia. Hyponatraemia correlated significantly with prolonged second stage of labour, instrumental delivery, and emergency caesarean section for failure to progress (P = 0.002).

Conclusions: Hyponatraemia is not uncommon following labour. Tolerance to a water load is diminished during labour; therefore, even moderate fluid volumes may cause hyponatraemia. Women should not be encouraged to drink excessively during labour. Oral fluids, when permitted, should be recorded, and intravenous administration of hypotonic fluids should be avoided. When abundant drinking is unrecognised or intravenous fluid administration liberal, life-threatening hyponatraemia may develop. The possibility that hyponatraemia may influence uterine contractility merits further investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Drinking / physiology*
  • Female
  • Humans
  • Hyponatremia / etiology*
  • Hypotonic Solutions / adverse effects
  • Obstetric Labor Complications / etiology*
  • Pregnancy
  • Prospective Studies


  • Hypotonic Solutions