HLA antigens influence resistance to lung carcinoma

Hum Immunol. 1991 Aug;31(4):236-40. doi: 10.1016/0198-8859(91)90093-o.


The concept of genetic factors playing a role in the pathogenesis of lung cancer has gained increased attention. The present study was undertaken to reexamine the question of HLA antigen association with carcinoma of the lung. In a study of 90 patients, a significant association occurred between HLA-DR7 and resistance to lung cancer, after accounting for smoking status and sex. HLA class I antigens were also implicated. These results suggest that major histocompatibility complex loci affect carcinoma of the lung.

Publication types

  • Review

MeSH terms

  • Carcinoma / etiology
  • Carcinoma / immunology*
  • Disease Susceptibility
  • Female
  • HLA Antigens / analysis*
  • Humans
  • Immunity, Innate
  • Lung Neoplasms / etiology
  • Lung Neoplasms / immunology*
  • Male
  • Sex Factors
  • Smoking


  • HLA Antigens