QMSim: a large-scale genome simulator for livestock

Bioinformatics. 2009 Mar 1;25(5):680-1. doi: 10.1093/bioinformatics/btp045. Epub 2009 Jan 28.


Summary: QMSim was designed to simulate large-scale genotyping data in multiple and complex livestock pedigrees. The simulation is basically carried out in two steps. In the first step, a historical population is simulated to establish mutation-drift equilibrium, and in the second step, recent population structures are generated, which can be very complex. A wide variety of genome architectures, ranging from infinitesimal model to single-locus model, can be simulated. The program is efficient in terms of computing time and memory requirements.

Availability: Executable versions of QMSim for Windows and Linux are freely available at http://www.aps.uoguelph.ca/~msargol/qmsim/.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Domestic / genetics*
  • Computational Biology / methods*
  • Genome*
  • Genotype
  • Pedigree
  • Software*