Green Tea Catechin Plus Caffeine Supplementation to a High-Protein Diet Has No Additional Effect on Body Weight Maintenance After Weight Loss

Am J Clin Nutr. 2009 Mar;89(3):822-30. doi: 10.3945/ajcn.2008.27043. Epub 2009 Jan 28.

Abstract

Background: Green tea (epigallocatechin gallate + caffeine) and protein each were shown to improve body weight maintenance after weight loss.

Objective: We investigated the effect of a green tea-caffeine mixture added to a high-protein (HP) diet on weight maintenance (WM) after body weight loss in moderately obese subjects.

Design: A randomized, placebo-controlled, double-blind parallel trial was conducted in 80 overweight and moderately obese subjects [age (mean +/- SD): 44 +/- 2 y; body mass index (BMI; in kg/m(2)): 29.6 +/- 2.0] matched for sex, age, BMI, height, body mass, and with a habitually low caffeine intake. A very-low-energy diet intervention during 4 wk was followed by 3 mo of WM; during the WM period, the subjects received a green tea-caffeine mixture (270 mg epigallocatechin gallate + 150 mg caffeine/d) or placebo, both in addition to an adequate protein (AP) diet (50-60 g protein/d) or an HP diet (100-120 g protein/d).

Results: Subjects lost 7.0 +/- 1.6 kg, or 8.2 +/- 2.0%, body weight (P < 0.001). During the WM phase, WM, resting energy expenditure, and fat-free mass (FFM) increased relatively in both the HP groups and in the AP + green tea-caffeine mixture group (P < 0.05), whereas respiratory quotient and body fat mass decreased, all compared with the AP + placebo group. Satiety increased only in both HP groups (P < 0.05). The green tea-caffeine mixture was only effective with the AP diet.

Conclusion: The green tea-caffeine mixture, as well as the HP diet, improved WM independently through thermogenesis, fat oxidation, sparing FFM, and, for the HP diet, satiety; a possible synergistic effect failed to appear.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Appetite / drug effects
  • Appetite / physiology
  • Blood Glucose / metabolism
  • Body Composition / physiology
  • Body Weight / drug effects*
  • Caffeine / administration & dosage*
  • Catechin / administration & dosage
  • Catechin / analogs & derivatives*
  • Dietary Proteins / administration & dosage*
  • Fatty Acids, Nonesterified / blood
  • Female
  • Glycerol / blood
  • Humans
  • Insulin / blood
  • Leptin / blood
  • Male
  • Middle Aged
  • Tea
  • Thermogenesis / drug effects
  • Thermogenesis / physiology
  • Triglycerides / blood
  • Weight Loss*
  • Young Adult

Substances

  • Blood Glucose
  • Dietary Proteins
  • Fatty Acids, Nonesterified
  • Insulin
  • Leptin
  • Tea
  • Triglycerides
  • Caffeine
  • Catechin
  • epigallocatechin gallate
  • Glycerol